abstract：BACKGROUND:Metastasis accounts for the majority of deaths from cancer. Although tumor microenvironment has been shown to have a significant impact on the initiation and/or promotion of metastasis, the mechanism remains elusive. We previously reported that HCT-8 colon cancer cells underwent a phenotypic transition from ...

journal_title：Molecular cancer

authors： Tang X,Kuhlenschmidt TB,Li Q,Ali S,Lezmi S,Chen H,Pires-Alves M,Laegreid WW,Saif TA,Kuhlenschmidt MS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). METHODS:The biological function of miR-139-5p was examined by cell growth, cell cycle and a...

journal_title：Molecular cancer

authors： Zhang L,Dong Y,Zhu N,Tsoi H,Zhao Z,Wu CW,Wang K,Zheng S,Ng SS,Chan FK,Sung JJ,Yu J

更新日期：2014-05-26 00:00:00

abstract：BACKGROUND:Colorectal cancers carrying the B-Raf V600E-mutation are associated with a poor prognosis. The purpose of this study was to identify B-RafV600E-mediated traits of cancer cells in a genetic in vitro model and to assess the selective sensitization of B-RafV600E-mutant cancer cells towards therapeutic agents. ...

journal_title：Molecular cancer

authors： Hirschi B,Gallmeier E,Ziesch A,Marschall M,Kolligs FT

更新日期：2014-05-24 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the number one cancer killer. Tumor-initiating cells (TICs) are responsible for tumor progression and recurrence. Emerging evidences suggest that small nucleolar RNAs (snoRNAs) play malfunctioning roles in lung tumorigenesis. This study aims to determine if snoRNAs have ...

journal_title：Molecular cancer

authors： Mannoor K,Shen J,Liao J,Liu Z,Jiang F

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the major causes of mortality. ABT-263 is a newly synthesized, orally available Bcl-2/xL inhibitor that shows promising efficacy in HCC therapy. ABT-263 inhibits the anti-apoptotic activity of Bcl-2 and Bcl-xL, but not Mcl-1. Previous reports have shown that ABT-263 u...

journal_title：Molecular cancer

authors： Wang B,Ni Z,Dai X,Qin L,Li X,Xu L,Lian J,He F

更新日期：2014-04-30 00:00:00

abstract：BACKGROUND:The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. METHOD...

journal_title：Molecular cancer

authors： Lassen A,Atefi M,Robert L,Wong DJ,Cerniglia M,Comin-Anduix B,Ribas A

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Atypical adenomatous hyperplasia (AAH) and squamous cell dysplasia (SCD) are associated with the development of malignant lesions in the lung. Accurate diagnosis of AAH and SCD could facilitate earlier clinical intervention and provide useful information for assessing lung cancer risk in human populations. D...

journal_title：Molecular cancer

authors： Lowe FJ,Shen W,Zu J,Li J,Wang H,Zhang X,Zhong L

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Medulloblastoma is the most common type of malignant brain tumor that afflicts children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients do poorly with significant morbidity. METHODS:To identify new molecular targets, we performed an integrated genomic analy...

journal_title：Molecular cancer

authors： Harris PS,Venkataraman S,Alimova I,Birks DK,Balakrishnan I,Cristiano B,Donson AM,Dubuc AM,Taylor MD,Foreman NK,Reigan P,Vibhakar R

更新日期：2014-03-24 00:00:00

abstract：BACKGROUND:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for ...

journal_title：Molecular cancer

authors： Sethi G,Chatterjee S,Rajendran P,Li F,Shanmugam MK,Wong KF,Kumar AP,Senapati P,Behera AK,Hui KM,Basha J,Natesh N,Luk JM,Kundu TK

更新日期：2014-03-21 00:00:00

abstract：BACKGROUND:Interferon regulatory factor-1 (IRF-1) is a master regulator of IFN-γ induced gene transcription. Previously we have shown that IRF-1 transcriptionally induces CEACAM1 via an ISRE (Interferon-Stimulated Response Element) in its promoter. CEACAM1 pre-mRNA undergoes extensive alternative splicing (AS) generati...

journal_title：Molecular cancer

authors： Dery KJ,Kujawski M,Grunert D,Wu X,Ngyuen T,Cheung C,Yim JH,Shively JE

更新日期：2014-03-21 00:00:00

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by the microenvironment surrounding tumor tissues, but relatively little is known about the key molecular in these cells that contribute to malignant pheno...

journal_title：Molecular cancer

authors： Yang M,Liu J,Shao J,Qin Y,Ji Q,Zhang X,Du J

更新日期：2014-03-02 00:00:00

abstract：BACKGROUND:Cancer is the result of a multistep process of genomic alterations, including mutations in key regulatory proteins that result in loss of balanced gene expression and subsequent malignant transformation. Throughout the various stages of colorectal carcinoma (CRC), complex genetic alterations occur, of which ...

journal_title：Molecular cancer

authors： Gaur S,Chen L,Ann V,Lin WC,Wang Y,Chang VH,Hsu NY,Shia HS,Yen Y

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:Tumor spreading is the major threat for cancer patients. The recently published anti-cancer drug salinomycin raised hope for an improved treatment by targeting therapy-refractory cancer stem cells. However, an unambiguous role of salinomycin against cancer cell migration and metastasis formation remains elus...

journal_title：Molecular cancer

authors： Kopp F,Hermawan A,Oak PS,Herrmann A,Wagner E,Roidl A

更新日期：2014-01-27 00:00:00

abstract：BACKGROUND:The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study investigated the underlying mechanism of Akt Ser-473 phosphorylation by UVB radiation. RESULTS:We found tha...

journal_title：Molecular cancer

authors： Tu Y,Ji C,Yang B,Yang Z,Gu H,Lu CC,Wang R,Su ZL,Chen B,Sun WL,Xia JP,Bi ZG,He L

更新日期：2013-12-24 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) have been documented as playing important roles in cancer development. In this study, we investigated the role of miR-124 in breast cancer and clarified the regulation of flotillin-1 (FLOT1) by miR-124. METHODS:The expression levels of miR-124 were examined in breast cancer cell lines and...

journal_title：Molecular cancer

authors： Li L,Luo J,Wang B,Wang D,Xie X,Yuan L,Guo J,Xi S,Gao J,Lin X,Kong Y,Xu X,Tang H,Xie X,Liu M

更新日期：2013-12-13 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Importantly, identification of pancreatic cancer stem cells (PCSCs) in pancreatic cancer cases has increased our unders...

journal_title：Molecular cancer

authors： Quan M,Wang P,Cui J,Gao Y,Xie K

更新日期：2013-12-10 00:00:00

abstract：BACKGROUND:Tumor cells produce various cytokines and chemokines that attract leukocytes. Leukocytes can amplify parenchymal innate immune responses, and have been shown to contribute to tumor promotion. Neutrophils are among the first cells to arrive at sites of inflammation, and the increased number of tumor-associate...

journal_title：Molecular cancer

authors： Gong L,Cumpian AM,Caetano MS,Ochoa CE,De la Garza MM,Lapid DJ,Mirabolfathinejad SG,Dickey BF,Zhou Q,Moghaddam SJ

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND:We previously identified TrkB as an oncogene involved in promoting metastasis in endometrial carcinoma (EC). Here, we sought to delineate the effect of changes in TrkB expression on the global profile of microRNAs (miRNAs) in EC cells and further investigated the correlation between the expression of certain...

journal_title：Molecular cancer

authors： Bao W,Wang HH,Tian FJ,He XY,Qiu MT,Wang JY,Zhang HJ,Wang LH,Wan XP

更新日期：2013-12-09 00:00:00

abstract：BACKGROUND AND METHODS:Stem or progenitor cells from healthy tissues have the capacity to co-segregate their template DNA strands during mitosis. Here, we set out to test whether breast cancer cell lines also possess the ability to asymmetrically segregate their template DNA strands via non-random chromosome co-segrega...

journal_title：Molecular cancer

authors： Liu W,Jeganathan G,Amiri S,Morgan KM,Ryan BM,Pine SR

更新日期：2013-11-15 00:00:00

abstract：BACKGROUND:Kinases downstream of growth factor receptors have been implicated in radioresistance and are, therefore, attractive targets to improve radiotherapy outcome in head and neck squamous cell carcinoma (HNSCC) patients. METHODS:An antibody-based array was used to quantify the expression levels of multiple phosp...

journal_title：Molecular cancer

authors： Stegeman H,Kaanders JH,Verheijen MM,Peeters WJ,Wheeler DL,Iida M,Grénman R,van der Kogel AJ,Span PN,Bussink J

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation of their expression is not fully understood. The pivotal transcription factor E2F1 which can induce ...

journal_title：Molecular cancer

authors： Feldstein O,Nizri T,Doniger T,Jacob J,Rechavi G,Ginsberg D

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary thyroid carcinoma (PTC). Genetic mechanisms underlying NRF2 pathway activation in PTC are not fully understood. Thus, we a...

journal_title：Molecular cancer

authors： Martinez VD,Vucic EA,Pikor LA,Thu KL,Hubaux R,Lam WL

更新日期：2013-10-20 00:00:00

abstract：BACKGROUND:Alterations in lipid metabolism are inherent to the metabolic transformations that support tumorigenesis. The relationship between the synthesis, storage and use of lipids and their importance in cancer is poorly understood. The human group X secreted phospholipase A2 (hGX sPLA2) releases fatty acids (FAs) f...

journal_title：Molecular cancer

authors： Pucer A,Brglez V,Payré C,Pungerčar J,Lambeau G,Petan T

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:The survival rate of head and neck squamous cell carcinoma (HNSCC) at advanced stage is poor, despite contemporary advances in treatment modalities. Recent studies have indicated that astrocyte elevated gene-1 (AEG-1), a single transmembrane protein without any known functional domains, is overexpressed in v...

journal_title：Molecular cancer

authors： Wang YP,Liu IJ,Chiang CP,Wu HC

更新日期：2013-09-24 00:00:00

abstract：:Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. Multimodal immunogenic cell death (ICD) together with autophagy often induced by O...

journal_title：Molecular cancer

authors： Bartlett DL,Liu Z,Sathaiah M,Ravindranathan R,Guo Z,He Y,Guo ZS

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with high mutational heterogeneity and a generally poor clinical outcome. Despite implicated roles of deregulated TP53, IGF-2 and Wnt signaling pathways, a clear genetic association or unique mutational link to the disease is still missing. Recent...

journal_title：Molecular cancer

authors： Korah R,Healy JM,Kunstman JW,Fonseca AL,Ameri AH,Prasad ML,Carling T

更新日期：2013-08-05 00:00:00

abstract：BACKGROUND:Patients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancer development. Thymoquinone (TQ) is considered the main compound of the volatile Nigella sativa seed oil and has been rep...

journal_title：Molecular cancer

authors： Lang M,Borgmann M,Oberhuber G,Evstatiev R,Jimenez K,Dammann KW,Jambrich M,Khare V,Campregher C,Ristl R,Gasche C

更新日期：2013-05-13 00:00:00

abstract：BACKGROUND:Co-Activator Arginine Methyltransferase 1(CARM1) is an Estrogen Receptor (ER) cofactor that remodels chromatin for gene regulation via methylation of Histone3. We investigated CARM1 levels and localization across breast cancer tumors in a cohort of patients of either European or African ancestry. METHODS:We...

journal_title：Molecular cancer

authors： Davis MB,Liu X,Wang S,Reeves J,Khramtsov A,Huo D,Olopade OI

更新日期：2013-05-10 00:00:00

abstract：BACKGROUND:Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%). MiR-497 was previously identified by our laboratory as a member of a miRNA expression signature, predictive o...

journal_title：Molecular cancer

authors： Creevey L,Ryan J,Harvey H,Bray IM,Meehan M,Khan AR,Stallings RL

更新日期：2013-03-26 00:00:00

abstract：BACKGROUND:Metastasis in medulloblastoma (MB) is associated with poor survival. Recent genetic studies revealed MB to comprise distinct molecular subgroups, including the sonic hedgehog (SHH) subgroup that exhibits a relatively high rate of progression. To identify targeted therapeutics against metastasis, a better und...

journal_title：Molecular cancer

authors： Yuan L,Zhang H,Liu J,Rubin JB,Cho YJ,Shu HK,Schniederjan M,MacDonald TJ

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:New therapies are urgently needed for patients with small cell lung cancer (SCLC). Chemotherapy and targeted therapies, including the Bcl-2 inhibitor ABT-737, may induce tumor cell autophagy. Autophagy can promote survival of cancer cells under stress and comprise a pathway of escape from cytotoxic therapies...

journal_title：Molecular cancer

authors： Zinn RL,Gardner EE,Dobromilskaya I,Murphy S,Marchionni L,Hann CL,Rudin CM

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation. METHODS:To quantify non-tumor and tumor DNA and RNA in the plasma of tumor-bearing rats and to correlate such levels with tumor ...

journal_title：Molecular cancer

authors： García-Olmo DC,Picazo MG,Toboso I,Asensio AI,García-Olmo D

更新日期：2013-02-04 00:00:00

abstract：BACKGROUND:ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin motifs) is a member of the ADAMTS family of metalloproteases. Here, we investigated mRNA and protein levels of ADAMTS-1 in normal and neoplastic tissues using qPCR, immunohistochemistry and immunoblot analyses, and we addressed the role of ADAMT...

journal_title：Molecular cancer

authors： Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,Jaeger RG,Nagai MA,Machado-Santelli GM

更新日期：2013-01-05 00:00:00

abstract：BACKGROUND:CD44 is considered as 'a' metastasis associated gene, despite the fact that it is an umbrella term for a group of molecules produced from a single gene by alternative splicing. However, little consideration is given to the above in the literature of colorectal carcinomas as well as other tumour types, leadin...

journal_title：Molecular cancer

authors： Bánky B,Rásó-Barnett L,Barbai T,Tímár J,Becságh P,Rásó E

更新日期：2012-11-14 00:00:00

abstract：BACKGROUND:Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA in tumor development. FLNA is also expressed in endothelial cells, which may be important for tumor a...

journal_title：Molecular cancer

authors： Nallapalli RK,Ibrahim MX,Zhou AX,Bandaru S,Sunkara SN,Redfors B,Pazooki D,Zhang Y,Borén J,Cao Y,Bergo MO,Akyürek LM

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced by promotor methylation in human cancers. Two members of this gene family, RASSF1A and RASSF5A ha...

journal_title：Molecular cancer

authors： Djos A,Martinsson T,Kogner P,Carén H

更新日期：2012-06-13 00:00:00

abstract：BACKGROUND:CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been postulated as a tumor suppressor gene. FINDINGS:We show for the first time tha...

journal_title：Molecular cancer

authors： van der Weyden L,Arends MJ,Rust AG,Poulogiannis G,McIntyre RE,Adams DJ

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Interferon Regulatory Factor 5 is a transcription factor that regulates the expression of genes involved in the response to viral infection and in the stimulation of the immune system. Moreover, multiple studies have demonstrated that it negatively regulates cell growth and oncogenesis, favoring cell differe...

journal_title：Molecular cancer

authors： Massimino M,Vigneri P,Fallica M,Fidilio A,Aloisi A,Frasca F,Manzella L

更新日期：2012-04-16 00:00:00

abstract：BACKGROUND:Metastasis is the leading cause of death among breast cancer patients. Identifying key cellular factors controlling invasion and metastasis of breast cancer cells should pave the way to new therapeutic strategies efficiently interfering with the metastatic process. PAX2 (paired box 2) transcription factor is...

journal_title：Molecular cancer

authors： Beauchemin D,Lacombe C,Van Themsche C

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Gefitinib is a tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) especially effective in tumors with activating EGFR gene mutations while EGFR wild-type non small cell lung cancer (NSCLC) patients at present do not benefit from this treatment.The primary site of gefitinib metabol...

journal_title：Molecular cancer

authors： Alfieri RR,Galetti M,Tramonti S,Andreoli R,Mozzoni P,Cavazzoni A,Bonelli M,Fumarola C,La Monica S,Galvani E,De Palma G,Mutti A,Mor M,Tiseo M,Mari E,Ardizzoni A,Petronini PG

更新日期：2011-11-23 00:00:00